Programmed Cell Death in Animal Development

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Programmed Cell Death in Animal Development

condense, and the organelles and plasma membrane retain their integrity in a process Kerr and his colleagues and Martin C. Raff Developmental Neurobiology Programme named apoptosis. The dead cells or their fragments are rapidly phagocytosed by neighboring cells or macro-phages before there is any leakage of the contents of the cells, and thus they do not induce an inflammatory London, WC1E 6BT ...

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Programmed cell death during animal development.

The formation of the hand during embryogenesis, the peeling of sunburned skin and the tremor associated with Parkinson's disease all result from a common process: cell death. Cell death occurs throughout the life span of the organism and represents the ultimate differentiative decision made by cells. Insight into the process of cell death will not only contribute to our understanding of basic d...

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Programmed Cell Death in Animal Development and Disease

Programmed cell death (PCD) plays a fundamental role in animal development and tissue homeostasis. Abnormal regulation of this process is associated with a wide variety of human diseases, including immunological and developmental disorders, neurodegeneration, and cancer. Here, we provide a brief historical overview of the field and reflect on the regulation, roles, and modes of PCD during anima...

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Programmed Cell Death in T Cell Development

The mammalian immune system is a complex network of many cell types and proteins that collectively coordinate a protective response against foreign entities. The immune system can be divided into two broad categories: innate and adaptive immunity. Adaptive immunity, which is primarily mediated by T and B lymphocytes, first arose in jawed vertebrates and has several distinct features from the mo...

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Programmed cell death in development and defense.

Around the time of this journal’s first volume, the concept of PCD, i.e. the cell’s active participation in its own demise, was introduced using the example of a plant cell infected by a fungus (1). This was 7 decades before the flurry of apoptosis research in animals. Death during an incompatible interaction between a plant and a pathogen was proposed to function as a physical block to further...

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ژورنال

عنوان ژورنال: Cell

سال: 1997

ISSN: 0092-8674

DOI: 10.1016/s0092-8674(00)81873-5